EDDM Response rate

I’ve read as many posts as I could find about EDDM. They say the response rate is between .5% and .67%. The posts also say to mail several times to the same route. So if I mail 2,500 pieces in March 2020 should I expect a return rate of between .5 -.67% or does that return not happen until the 4th or 5th mailing?

It seems that if the return is not based if off each individual mailing that the numbers do t work.

Thank you for any insight.